Yes, they are compatible. However, you will need a license for every site.
Eg: If you have subsites as,
www.domainname/site1
www.domainname/site2
www.domainname/site3
Activate the license on every subsite ( site1, site2, site3).
Our system recognizes the name of the URL www.domainname/site1 different from www.domainname/site2. This means, to activate the plugins on all sites, you will need to buy a separate license for each subsite.